… with mature secretory products, formation of pancreatic islets, … islets, islet vascularity is
decreased in proportion to islet size, … on islet growth, development, and function will be important …

… islet graft failure and graft loss. This review summarises our understanding of the role of
vascular endothelial growth factor-A … that promoting early graft vascularisation in clinical islet …

… of the cells in the pancreatic islets. Dysfunction of these cells … to encourage the islet
vascularisation required for basement … contact with intra-islet vascular endothelial cells or …

… [106] but also may alter the morphology of pancreatic islets and … -A dose to potentiate islet
vascularization is subject to further … A dysfunctional intra-islet vascular endothelium may …

… Pancreatic islets are discrete, spherical clusters of cells … endothelial growth factor A (VEGF-A),
which binds VEGF … -A expression not only reduces islet vascularity 10-fold but also leads …

… However, the islet also includes several important non-endocrine cell types, … exist in islet
vascularisation and morphology in human islets compared … Vascular endothelial growth factor …

… Thus, there is an urgent need to develop strategies to improve the … Pancreatic islets are
highly vascularized and are known to express VEGF-A [22], [26]. Furthermore, the development …

… Vascular endothelial growth factor A (VEGF-A) has been … well as impaired islet vascularization
and endothelial fenestration.59-… that proper vasculature is required for lung development (…

… basic vascular anatomy of the adult pancreas, as well as islet … and how the pancreatic
epithelium becomes vascularized, as … Cell type specific expression of vascular endothelial growth …

… The primary function of pancreatic islets is to regulate blood … mediated by vascular endothelial
growth factor-A (VegfA) … To determine if Vegf signaling is required for islet vascularization, …